Dimerization of translationally controlled tumor protein is essential for its cytokine-like activity.
BACKGROUND:Translationally Controlled Tumor Protein (TCTP) found in nasal lavage fluids of allergic patients was named IgE-dependent histamine-releasing factor (HRF).Human recombinant HRF (HrHRF) has been recently reported to be much less effective than HRF produced from activated mononuclear cells (HRFmn).METHODS AND FINDINGS:We found that only NH